Best Supplements for Stress Relief in 2025: A Clear Guide

Stress isn’t new—but how we manage it can be.

Between work, family, and the endless notifications on our phones, stress has quietly woven itself into daily life. It’s easy to brush off, to call it “just part of the grind.” But when stress lingers, it takes a toll—on mood, sleep, performance, even skin.

At Novum, we believe wellness should feel clear, not cluttered. So we’ve stripped away the noise and focused on what works. Here’s your straightforward guide to the best supplements for stress relief in 2025—no hype, just what you need to know.

The Science of Stress (Briefly)

Stress triggers your body’s fight-or-flight response. Cortisol (the stress hormone) rises. Your nervous system goes on high alert. Short term? It helps you focus. Long term? It wears you down—impacting sleep, energy, immune function, and even how you show up in life.

Supplementing can support your body’s ability to manage stress, keeping those internal systems balanced. But not all supplements are equal.

Let’s cut to the ones that matter.

Top Supplements for Stress Relief in 2025

1. Magnesium Glycinate

Magnesium plays a role in over 300 biochemical processes in the body—including how your nervous system functions. When stress runs high, magnesium levels often run low.

Magnesium Glycinate is a specific form known for its calming effects and high absorption rate. Unlike other types, it’s gentle on digestion and helps relax muscles, quiet the mind, and support deep sleep.

  • Best for: Evening routines, easing muscle tension, promoting rest.

  • How to use: 200-400 mg daily, ideally before bed.

(Novum Still’s Magnesium Glycinate is formulated for optimal absorption—no unnecessary fillers, just what your body needs.)

2. Ashwagandha

This ancient adaptogen has stood the test of time. Ashwagandha helps the body adapt to stress—reducing cortisol levels and supporting a more balanced mood.

Clinical studies continue to show its effectiveness in promoting stress resilience, improving sleep quality, and even enhancing cognitive function under pressure.

  • Best for: All-day stress support, mental clarity, sleep improvement.

  • How to use: 300-600 mg daily, often split into morning and evening doses.

3. L-Theanine

Found naturally in green tea, L-Theanine promotes calm focus without sedation. It smooths the edges of stress while supporting alpha brainwave activity—the same brainwaves associated with relaxed alertness.

When combined with caffeine, it enhances focus without the jitters. On its own, it’s a subtle way to take the edge off during high-stress moments.

  • Best for: Daytime calm, pairing with coffee or tea, focus under pressure.

  • How to use: 100-200 mg as needed.

4. 5-HTP (5-Hydroxytryptophan)

5-HTP is a precursor to serotonin, the neurotransmitter tied to mood, sleep, and well-being. Supporting serotonin levels helps balance mood and improve sleep patterns—two key areas impacted by chronic stress.

Unlike some mood-support supplements, 5-HTP works naturally with your body’s systems. It’s especially helpful for those whose stress shows up as restlessness, low mood, or disrupted sleep.

  • Best for: Mood balance, easing emotional stress, sleep support.

  • How to use: 50-200 mg, usually in the evening.

5. Rhodiola Rosea

Another adaptogen, Rhodiola Rosea helps regulate cortisol levels while boosting mental energy and resilience. It’s been used for centuries in harsh climates to improve stamina and reduce fatigue.

For those whose stress feels more like burnout or exhaustion, Rhodiola can provide support without overstimulation.

  • Best for: Mental endurance, combating fatigue, daytime stress resilience.

  • How to use: 200-400 mg daily, preferably in the morning.

How to Choose What’s Right for You

Here’s where simplicity matters.

You don’t need all five supplements. Start with one or two based on how stress shows up for you:

  • Feeling wired at night? → Magnesium Glycinate + 5-HTP

  • Foggy during the day? → Rhodiola Rosea + L-Theanine

  • Overwhelmed in general? → Ashwagandha as a daily foundation

Wellness isn’t about stacking every supplement possible—it’s about finding what works and making it part of your ritual.

At Novum, we design our products to fit seamlessly into your day. No complicated stacks. No unnecessary additives. Just science-driven, ritual-ready formulas that support you—without overcomplicating things.

Ritual, Not Routine

We talk about ritual because it’s more than taking a pill. It’s about creating space to support yourself. Whether it’s a capsule of magnesium before bed, a moment of stillness, or taking a breath between meetings—small actions create lasting change.

Final Thoughts: Keep It Simple, Keep It Consistent

Stress isn’t going anywhere. But how you manage it can evolve. The best supplements for stress relief in 2025 aren’t about chasing trends—they’re about supporting your body’s natural rhythms.

At Novum, we believe in meeting that need with clarity, not clutter. Explore our Novum Still collection to discover supplements that fit your life—thoughtfully formulated, minimal by design.

Your body. Your era.

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